footshock module Search Results


footshock module  (AFASCI INC)
90
AFASCI INC footshock module
Direct activation of GIRK channels with ML297 does not cause impairment of fear-conditioned responses, and novel object recognition. (A) In the contextual fear conditioning test, representative mouse moving trajectories prior to <t>footshock</t> in the training day are shown. (B) Twenty-four hours after footshocks (training) with subsequent re-exposure to context are shown in (A) and (B), respectively. (C) Freezing % in baseline and contexual-conditioned under ML297 (30 mg/kg, i.p.) treatment or vehicle condition was plotted. There are sigificant differences in contexual freezing time compared with baseline but insigficant differences between ML297 and control groups (ANOVA, p < 0.01 among the four groups; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). The representative mouse moving trajectories before, during, and after 5-tone is shown in (D), (E), and (F), respectively. (G–H) Time courses of traveling distance in 1 min bins indicate that tones dramatically decreased locomotion with partial recovery. (I) Averaged rearing activity counts are shown in the histogram before, during, and after 5-tone under ML297 or vehicle treatment conditions. (ANOVA, p < 0.05 among the six conditions; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). (J) Ability of novel object recognition was quantified by the % exploring time spent toward the novel object over total exploring time toward the familiar (A) and novel objects (B) under ML297 (30 mg/kg, i.p.), diazepam (3 mg/kg, i.p.), or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p < 0.01 among the six conditions; post hoc PLSD between exploring A and B objects, ***p > 0.001). Total exploring time toward two identical objects on training session and on test session toward the familiar (A) and novel objects (B) under ML297, diazepam, or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p = 0.14 among the six conditions).
Footshock Module, supplied by AFASCI INC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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footshock module - by Bioz Stars, 2026-04
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Direct activation of GIRK channels with ML297 does not cause impairment of fear-conditioned responses, and novel object recognition. (A) In the contextual fear conditioning test, representative mouse moving trajectories prior to footshock in the training day are shown. (B) Twenty-four hours after footshocks (training) with subsequent re-exposure to context are shown in (A) and (B), respectively. (C) Freezing % in baseline and contexual-conditioned under ML297 (30 mg/kg, i.p.) treatment or vehicle condition was plotted. There are sigificant differences in contexual freezing time compared with baseline but insigficant differences between ML297 and control groups (ANOVA, p < 0.01 among the four groups; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). The representative mouse moving trajectories before, during, and after 5-tone is shown in (D), (E), and (F), respectively. (G–H) Time courses of traveling distance in 1 min bins indicate that tones dramatically decreased locomotion with partial recovery. (I) Averaged rearing activity counts are shown in the histogram before, during, and after 5-tone under ML297 or vehicle treatment conditions. (ANOVA, p < 0.05 among the six conditions; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). (J) Ability of novel object recognition was quantified by the % exploring time spent toward the novel object over total exploring time toward the familiar (A) and novel objects (B) under ML297 (30 mg/kg, i.p.), diazepam (3 mg/kg, i.p.), or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p < 0.01 among the six conditions; post hoc PLSD between exploring A and B objects, ***p > 0.001). Total exploring time toward two identical objects on training session and on test session toward the familiar (A) and novel objects (B) under ML297, diazepam, or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p = 0.14 among the six conditions).

Journal: Sleep

Article Title: Direct activation of G-protein-gated inward rectifying K + channels promotes nonrapid eye movement sleep

doi: 10.1093/sleep/zsy244

Figure Lengend Snippet: Direct activation of GIRK channels with ML297 does not cause impairment of fear-conditioned responses, and novel object recognition. (A) In the contextual fear conditioning test, representative mouse moving trajectories prior to footshock in the training day are shown. (B) Twenty-four hours after footshocks (training) with subsequent re-exposure to context are shown in (A) and (B), respectively. (C) Freezing % in baseline and contexual-conditioned under ML297 (30 mg/kg, i.p.) treatment or vehicle condition was plotted. There are sigificant differences in contexual freezing time compared with baseline but insigficant differences between ML297 and control groups (ANOVA, p < 0.01 among the four groups; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). The representative mouse moving trajectories before, during, and after 5-tone is shown in (D), (E), and (F), respectively. (G–H) Time courses of traveling distance in 1 min bins indicate that tones dramatically decreased locomotion with partial recovery. (I) Averaged rearing activity counts are shown in the histogram before, during, and after 5-tone under ML297 or vehicle treatment conditions. (ANOVA, p < 0.05 among the six conditions; post hoc PLSD between two treatment groups, p > 0.05, n = 8/group). (J) Ability of novel object recognition was quantified by the % exploring time spent toward the novel object over total exploring time toward the familiar (A) and novel objects (B) under ML297 (30 mg/kg, i.p.), diazepam (3 mg/kg, i.p.), or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p < 0.01 among the six conditions; post hoc PLSD between exploring A and B objects, ***p > 0.001). Total exploring time toward two identical objects on training session and on test session toward the familiar (A) and novel objects (B) under ML297, diazepam, or vehicle treatment conditions at 24 hr after the training (n = 8/group, ANOVA, p = 0.14 among the six conditions).

Article Snippet: Typically each SWD consists of 4–7 Hz large amplitude brain electrical waveforms lasting for 3–5 s. Contextual- and tone-conditioning fear tests Mice (C57BL/6, male, approximately 3 months old) were subjected to footshock fear-conditioning on the training day using the footshock module (AfaSci, Inc.), which consists of a metal grid and an electric stimulation generator controlled by the behavior monitor system.

Techniques: Activation Assay, Control, Activity Assay